L’ampk : un lien entre métabolisme et reproduction ?

摘要: 5'AMP-activated protein kinase (AMPK) is a serine/threonine that acts as fuel gauge in regulating energy metabolism. It restores cellular ATP levels by switching on catabolic pathways and off anabolic pathways. Some evidence indicates AMPK could be also implicated reproductive functions such granulosa cell steroidogenesis nuclear oocyte maturation several species. metabolic hormones leptin, resistin, adiponectin (three adipokines) ghrelin may part act through the signaling. These are involved control of at hypothalamus-pituitary-gonadal axis level both male female. Thus, one signaling controlling interactions between balance reproduction. The system tightly coupled with balance, thereby abnormalities can lead to development some physiopathological situations polycystic ovary syndrome (PCOS). Women PCOS show altered fertility mostly associated disorders insulin-resistance, hyperinsulinemia and/or dyslipidemia. Metformin, an insulin-sensitizer, used for treatment women PCOS. subnormal balance. Recent studies mechanism action metformin. it therapeutic target. However, further investigations necessary elucidate tissues.