Significant reduction of red blood cell transfusion requirements by changing from a double-unit to a single-unit transfusion policy in patients receiving intensive chemotherapy or stem cell transplantation

摘要: Background Traditionally, single-unit red blood cell transfusions were believed to be insufficient treat anemia, but recent data suggest that they may lead a safe reduction of transfusion requirements. We tested this hypothesis by changing from double- policy.Design and Methods performed retrospective cohort study in patients with hematologic malignancies receiving intensive chemotherapy or hematopoietic stem transplantation. The major end-points the total number units per therapy cycle day aplasia. comprised 139 who received 272 cycles. Overall 2212 administered 1548 transfusions.Results During periods policies, one unit was transfused 25% 84% cases median two one, respectively. Single-unit led usage 24% aplasia day, not associated higher out-patient frequency. In multivariate analysis, resulted 2.7 treatment (P=0.001). pre-transfusion hemoglobin levels lower during period (median 61 g/L versus 64 g/L) more values 60 gl/L less (47% 26%). There no evidence severe bleeding platelet overall survival similar both cohorts.Conclusions Implementing policy saves and, thereby, reduces risks allogeneic transfusions.