Red blood cell transfusion in clinical practice

摘要: Every year, about 75 million units of blood are collected worldwide. Red cell (RBC) transfusion is one the few treatments that adequately restore tissue oxygenation when oxygen demand exceeds supply. Although respiratory function has been studied intensively, trigger for RBC remains controversial, and doctors rely primarily on clinical experience. Laboratory assays indicate failing would be ideal to guide need transfusion, but none proved easy, reproducible, sensitive regional hypoxia. The importance RBCs storage lesion (ie, time-dependent metabolic, biochemical, molecular changes stored cells undergo) poorly understood. can filtered, washed, frozen, or irradiated specific indications. Donor screening testing have dramatically reduced infectious risks in developed world, infection a major hazard developing countries, where 13 not tested HIV hepatitis viruses. Pathogen inactivation techniques trials RBCs, available use. Despite serious immunological non-immunological complications, holds therapeutic index many common medications.