Mutation of the Ki-ras protooncogene in human endometrial hyperplasia and carcinoma.

摘要: Abstract Previous studies have demonstrated that some human endometrial carcinomas contain an activating point mutation in codon 12 of the Ki- ras protooncogene. To examine hypothesis this may occur at earlier stage neoplastic progression endometrium, we analyzed 89 samples premalignant hyperplasia and additional 84 carcinoma for mutations 12. Mutations were found all three types hyperplasia, simple, complex, atypical, with no clear evidence a differential distribution any particular type. Furthermore, overall incidence specimens (16%) was similar to detected (18%), indicating represent early event subset carcinomas. When tissue segregated as country origin, frequency approximately 2-fold higher from Japan than United States, where incidence, clinicopathological characteristics, risk factors differ dramatically. There apparent correlation, however, between pathological, histological, or clinical parameter examined, except survival. The presence inversely associated death disease, suggesting molecular feature characterize good prognosis.