Molecular Pathogenesis of Endometrial Cancer

摘要: The molecular pathogenesis of a neoplasm is multistep process in which normal human cell undergoes series progressive changes, eventually resulting cancerous (1). Genetic mutations are important etiologic factors the development cancer. More specifically, cancer consequence abnormal expression or function specific cellular genes, oncogenes, and tumor-suppressor genes. These alterations thought to occur by one two routes: Mutations can somatically through inheritance via germline. routes correspond sporadic hereditary classifications cancers. increased incidence most tumors older population suggests that several events must take place for this transformation occur. A genetic model tumorigenesis has been proposed illustrates colorectal (2). It likely be applied study other neoplasms tumor less well defined, such as endometrial carcinoma. This application would turn benefit researchers defining role tamoxifen (TAM)