Amplification and Overexpression of HER-2/neu (c-erbB2) in Endometrial Cancers: Correlation with Overall Survival

摘要: Few molecular genetic alterations have been identified in endometrial cancers that are associated with poor clinical outcome. Overexpression of HER-2/neu, transforming growth factor alpha, and p53 proteins all prognosis women cancer. In this study, the level HER-2/neu gene amplification expression was characterized 92 cancers. Fluorescence situ hybridization (FISH) used to characterize copy number, immunohistochemistry expression. Forty-seven 90 (52%) were as showing moderate or high immunostaining. detected 17 81 (21%) cases. Immunohistochemical staining FISH results both available for 80 Fourteen these cases showed immunostaining amplification. Clinical follow-up information 76 study. Women whose cancer exhibited by had a shorter overall survival than lacked (P = 0.018). Likewise, tumors lower cumulative low log rank analysis < 0.0001). Multivariate rates revealed overexpression be an independent predictor 0.0163). Among those patients overexpression, adjuvant chemotherapy radiation therapy improved 0.039). However, among tumor not treatment.