Synthesis of cyclopentadienyltricarbonylrhenium substituted benzhydryl species and oestrogen receptor binding properties
作者： D. Plażuk , F. Le Bideau , A. Pérez-Luna , E. Stéphan , A. Vessières
DOI: 10.1002/AOC.1034
关键词: Transmetalation 、 Reaction conditions 、 Binding properties 、 Methyllithium 、 Fulvene 、 Nucleophile 、 Chemistry 、 Stereochemistry 、 Oestrogen receptor
摘要: 6-(4-Methoxyphenyl)fulvene has been efficiently engaged in a process implying nucleophilic attack of methyllithium followed by transmetallation reaction the presence different organorhenium sources {XRe(CO)5: X = Cl, Br, OTf; BrRe(CH3CN)2(CO)3, [BrRe(CO)3THF]2} to afford corresponding cyclopentadienyltricarbonylrhenium-substituted compound. This study allowed us determine best complex for that transformation, and similar conditions were used with success provide new potential radiopharmaceuticals cold series. One these compounds [the (4,4′-dihydroxybenzhydryl)cyclopentadienyltricarbonylrhenium] displays good recognition α form oestrogen receptor. Copyright © 2006 John Wiley & Sons, Ltd.
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