New and efficient routes to biomolecules substituted with cyclopentadienyltricarbonylrhenium and -technetium derivatives.

摘要: The small, compact, robust, and nonpolar units of [CpM(CO)3] (M = Re, Tc) coupled with biomolecules may be considered as bioorganometallic entities potential interest in the field medicinal chemistry. However, short half-life useful radionuclides (186Re t1/2 3.7 d, 188Re 16.8 h, 99mTc 6 h), risks inherent their use, cost have led chemists to search for novel synthetic strategies that allow rapid introduction moiety a late step course synthesizing target molecule. present paper describes different recently reported literature tackle this problem.