Control of Surface Wound Infection: Skin Versus Synthetic Grafts

作者: Dennis G. Saymen , Paul Nathan , Ian Alan Holder , Edward O. Hill , Bruce G. Macmillan

DOI: 10.1128/AM.25.6.921-934.1973

关键词: MicrobiologyPanniculusImmunologyHost responseBiopsySurface woundBacterial populationStainingPolyhydroxyethylmethacrylateBiologyPseudomonas aeruginosaGeneral Pharmacology, Toxicology and PharmaceuticsGeneral Biochemistry, Genetics and Molecular BiologyGeneral Immunology and MicrobiologyGeneral Medicine

摘要: Auto-, iso-, or xenografts of skin and synthetics placed on surface wounds freshly contaminated with Pseudomonas aeruginosa stabilizes the wound bacterial population in rats over a 24-h period. When these contained contamination established for 24 h prior to grafting, only synthetic polyhydroxyethylmethacrylate were effective lowering initial concentration. Polyurethane foam nylon velour not infection model. Skin 2 longer appeared equilibrate underlying muscle so that count per milligram was similar muscle. It suggested this preparation would be useful obtain an estimate without biopsy infected grafts place significantly lowered infection. A second decrease occurred between 4 after grafting. Histological studies exposed panniculus showed leukocytes tend migrate from its base. appear reverse white cell migration cells move toward preservation normal staining characteristics is alteration movement graft application might modify function result greater bactericidal activity. Apparently, lower levels by modifying host response contamination.

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