Effect of Acute Ethanol on Striatal Dopamine Neurotransmission in Ambulatory Rats

摘要: The effect of ethanol on evoked dopamine release in the caudate putamen has been measured behaving animals with vivo electrochemistry. Dopamine was fast-scan cyclic voltammetry adult male rats to resolve competing processes uptake and release. Ethanol dose dependently decreased efflux compared saline-treated animals: 89% controls 0.5 g/kg, 70% 1 34% 2.5 18% 5 g/kg. This decrease not due a change uptake, as by rate disappearance after stimulation, therefore can be attributed Additionally, it mediated biosynthesis, L-DOPA accumulation NSD 1015 administration. selective inhibitor GBR 12909 compensated for effects high doses Moreover, induced faster restoration righting reflex sedated but ethanol. In brain slices containing putamen, suppressed only at highest tested (200 mM). difference responses between slice intact animal indicates that exerts its cell body regions neurons well terminals. These neurochemical results, combined published accounts microdialysis measures extracellular electrophysiological recordings neurons, demonstrate profound whose net result is suppression neurotransmission doses.