Matters of Life and Death in the Immune System

作者: Christopher P. Dillon , Douglas R. Green

DOI: 10.1007/978-1-60327-381-7_18

关键词: LymphocyteBiologyBcl-2 familyAntigenMyeloidApoptosisNeuroscienceOrganismImmune system

摘要: Apoptotic function in the immune response is a matter of life and death for an organism. A robust vital survival any organism fighting infection. In order effective to be launched, apoptotic mechanisms used shape that have properly. Many more cells are generated than required produce few can effectively discriminate between respond foreign antigens within vast pool self peptides. These undergo gauntlet checkpoints during after development ensure they able fully challenges. Subsets even use these same proapoptotic pathways control their targets. Indeed, understanding matters system really means how apoptosis shapes almost every aspect response.

参考文章(124)
Edith M. Janssen, Edward E. Lemmens, Tom Wolfe, Urs Christen, Matthias G. von Herrath, Stephen P. Schoenberger, CD4 + T cells are required for secondary expansion and memory in CD8 + T lymphocytes Nature. ,vol. 421, pp. 852- 856 ,(2003) , 10.1038/NATURE01441
Pierre Vassalli, Shozo Izui, J. C. Cerottini, R. Ceredig, P. F. Piguet, J. L. Davignon, H. R. MacDonald, R. C. Budd, Functional analysis of T cell subsets from mice bearing the lpr gene. Journal of Immunology. ,vol. 135, pp. 2423- 2428 ,(1985)
David C. Gondek, Li-Fan Lu, Sergio A. Quezada, Shimon Sakaguchi, Randolph J. Noelle, Cutting Edge: Contact-Mediated Suppression by CD4+CD25+ Regulatory Cells Involves a Granzyme B-Dependent, Perforin-Independent Mechanism Journal of Immunology. ,vol. 174, pp. 1783- 1786 ,(2005) , 10.4049/JIMMUNOL.174.4.1783
C C Goodnow, J C Rathmell, Effects of the lpr mutation on elimination and inactivation of self-reactive B cells. Journal of Immunology. ,vol. 153, pp. 2831- 2842 ,(1994)
A. Strasser, A. W. Harris, D. C. Huang, P. H. Krammer, S. Cory, Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. The EMBO Journal. ,vol. 14, pp. 6136- 6147 ,(1995) , 10.1002/J.1460-2075.1995.TB00304.X
Stephen A. Renshaw, Jasvir S. Parmar, Vanessa Singleton, Sarah J. Rowe, David H. Dockrell, Steven K. Dower, Colin D. Bingle, Edwin R. Chilvers, Moira K. B. Whyte, Acceleration of human neutrophil apoptosis by TRAIL. Journal of Immunology. ,vol. 170, pp. 1027- 1033 ,(2003) , 10.4049/JIMMUNOL.170.2.1027
D S Pisetsky, A P Dang-Vu, J B Weinberg, Functional alterations of macrophages in autoimmune MRL-lpr/lpr mice. Journal of Immunology. ,vol. 138, pp. 1757- 1761 ,(1987)
Stephen P. Schoenberger, Rene E. M. Toes, Ellen I. H. van der Voort, Rienk Offringa, Cornelis J. M. Melief, T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions Nature. ,vol. 393, pp. 480- 483 ,(1998) , 10.1038/31002
Vladimir P. Badovinac, Kelly A. Nordyke Messingham, Thomas S. Griffith, John T. Harty, TRAIL deficiency delays, but does not prevent, erosion in the quality of "helpless" memory CD8 T cells. Journal of Immunology. ,vol. 177, pp. 999- 1006 ,(2006) , 10.4049/JIMMUNOL.177.2.999