Acceleration of human neutrophil apoptosis by TRAIL.
作者： Stephen A. Renshaw , Jasvir S. Parmar , Vanessa Singleton , Sarah J. Rowe , David H. Dockrell
DOI: 10.4049/JIMMUNOL.170.2.1027
关键词:
摘要: Neutrophil granulocytes have a short lifespan, with their survival limited by constitutive program of apoptosis. Acceleration neutrophil apoptosis following ligation the Fas death receptor is well-documented and TNF-alpha also has transient proapoptotic effect. We studied role ligand TRAIL in human neutrophils. identified presence mRNAs for TRAIL, TRAIL-R2, TRAIL-R3, cell surface expression TRAIL-R2 -R3 populations. specifically accelerated exposure to leucine zipper-tagged form which mimics TRAIL. Using blocking Abs receptors, TRAIL-R1:FcR fusion protein, we excluded regulating No additional effect zipper was treatment neutrophils gliotoxin, an inhibitor NF-kappaB, suggesting does not activate NF-kappaB did induce chemotactic response. The susceptibility TRAIL-mediated suggests regulation inflammation may provide mechanism clearance from sites inflammation.
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