Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations.
作者： Peter C. Maisonpierre , Michelle M. Le Beau , Rafael Espinosa , Nancy Y. Ip , Leonardo Belluscio
DOI: 10.1016/0888-7543(91)90436-I
关键词: Neurotrophin 、 Biology 、 Neurotrophin-3 、 Brain-derived neurotrophic factor 、 Homology (biology) 、 Genetics 、 Neurotrophic factors 、 Nerve growth factor 、 Tropomyosin receptor kinase B 、 Gene
摘要: The development and maintenance of the vertebrate nervous system depends upon neuronal survival proteins known as neurotrophic factors. Nerve growth factor (NGF) remains best characterized molecule. Brain-derived (BDNF) neurotrophin-3 (NT-3) are two recently cloned factors that homologous to NGF. Here we describe molecular cloning human rat genes encoding BDNF, well isolation NT-3 gene. On basis comparison our genomic cDNA clones with those previously isolated BDNF cDNAs, make inferences about structures processed transcripts derived from neurotrophin protein precursors they encode. We demonstrate mature form is identical in all mammals examined, same true NT-3. Furthermore, respective tissue-distributions specificities also conserved among mammals. Finally, localize gene (gene symbol designated BDNF) chromosome 11, band p13, NTF3) 12, p13.
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sci-hub.se 参考文章(37)
Tom Glaser, Elise Rose, Helvise Morse, David Housman, Carol Jones, A panel of irradiation-reduced hybrids selectively retaining human chromosome 11p13: Their structure and use to purify the WAGR gene complex Genomics. ,vol. 6, pp. 48- 64 ,(1990) , 10.1016/0888-7543(90)90447-3
H.-H. Ropers, I.W. Craig, Report of the committee on the genetic constitution of chromosomes 12 and 13. Cytogenetic and Genome Research. ,vol. 51, pp. 259- 279 ,(1988) , 10.1159/000132794
A. Rosenthal, D.V. Goeddel, T. Nguyen, M. Lewis, A. Shih, G.R. Laramee, K. Nikolics, J.W. Winslow, Primary structure and biological activity of a novel human neurotrophic factor Neuron. ,vol. 4, pp. 767- 773 ,(1990) , 10.1016/0896-6273(90)90203-R
J.-L. Mandel, H.F. Willard, R.L. Nussbaum, K.E. Davies, G. Romeo, Report of the committee on the genetic constitution of the X chromosome Cytogenetic and Genome Research. ,vol. 55, pp. 254- 313 ,(1988) , 10.1159/000132662
T Glaser, J Lane, D Housman, A mouse model of the aniridia-Wilms tumor deletion syndrome Science. ,vol. 250, pp. 823- 827 ,(1990) , 10.1126/SCIENCE.2173141
H. Persson, P. Ernfors, C. F. Ibanez, T. Ebendal, L. Olson, Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 87, pp. 5454- 5458 ,(1990) , 10.1073/PNAS.87.14.5454
Scott R. Whittemore, Åke Seiger, The expression, localization and functional significance of β-nerve growth factor in the central nervous system Brain Research. ,vol. 434, pp. 439- 464 ,(1987) , 10.1016/0165-0173(87)90008-7
Andreas Hohn, Joachim Leibrock, Karen Bailey, Yves-Alain Barde, Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family Nature. ,vol. 344, pp. 339- 341 ,(1990) , 10.1038/344339A0
P. Lichter, T. Cremer, J. Borden, L. Manuelidis, D. C. Ward, Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries Human Genetics. ,vol. 80, pp. 224- 234 ,(1988) , 10.1007/BF01790090
Viktor Hamburger, The journey of a neuroembryologist. Annual Review of Neuroscience. ,vol. 12, pp. 1- 12 ,(1989) , 10.1146/ANNUREV.NE.12.030189.000245