Anti-inflammatory and analgesic activity of Bouchea fluminensis.
作者： VB Costa , CS Coube , BG Marinho , ME Matheus , SG Leitão
DOI: 10.1016/S0367-326X(03)00049-2
关键词: Anti-inflammatory 、 Oleanolic acid 、 Oral administration 、 Chemistry 、 Biological activity 、 Analgesic 、 Ursolic acid 、 (+)-Naloxone 、 Pharmacology 、 Opioid
摘要: Dried leaves extract from Bouchea fluminensis was assessed in anti-inflammatory (mouse paw edema) and analgesic models (acetic acid-induced writhings hot plate). Oral pretreatment of animals with a crude mixture (IG) purified ursolic, oleanolic micromeric acids (IG-59) at doses ranging 1 to 30 mg/kg, significantly inhibited carrageenin-induced edema formation. At the same doses, IG IG-59 also exhibited peripheral central activity. It seems that B. triterpenes develop their effect through opioid receptors, due observation naloxone reverted activity on plate model.
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