Molecular Ultrasound Imaging Using Contrast Agents Targeting Endoglin, Vascular Endothelial Growth Factor Receptor 2 and Integrin

摘要: Expression levels of endoglin, αv integrin and vascular endothelial growth factor receptor 2 (VEGFR2) were investigated using targeted, contrast-enhanced ultrasonography in murine melanoma tumor models. Microvasculature expression biomarkers specific contrast agents conjugated with biotinylated monoclonal antibodies. Ultrasound signal intensity from bound was evaluated two groups mice: control mice treated sorafenib. analyzed by immunohistochemistry. Endoglin more highly expressed than VEGFR2. decreased the sorafenib group, whereas it tended to increase time group. Targeted ultrasound may be used for non-invasive longitudinal evaluation angiogenesis during or therapeutic treatment preclinical studies. protein, which plays an important role angiogenesis, seems a target interest detection cancer prediction efficacy.