A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies.
作者： Steffen Boettcher , Peter G Miller , Rohan Sharma , Marie McConkey , Matthew Leventhal
关键词: Myeloid 、 Point mutation 、 Leukemia 、 Biology 、 Missense mutation 、 Mutation 、 Myeloid leukemia 、 Gene 、 Genetics 、 Loss function
摘要: TP53, which encodes the tumor suppressor p53, is the most frequently mutated gene in human cancer. The selective pressures shaping its mutational spectrum, dominated by missense …
sciencemag.org参考文章(55)
Patrick Chène, Adriano Aguzzi, Daniela Rüedi, Michael A. Klein, Marie-France Hamou, Monika E. Hegi, p53 transdominance but no gain of function in mouse brain tumor model. Cancer Research. ,vol. 60, pp. 3019- 3024 ,(2000)
Jiajun Zhu, Morgan A. Sammons, Greg Donahue, Zhixun Dou, Masoud Vedadi, Matthäus Getlik, Dalia Barsyte-Lovejoy, Rima Al-awar, Bryson W. Katona, Ali Shilatifard, Jing Huang, Xianxin Hua, Cheryl H. Arrowsmith, Shelley L. Berger, Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth Nature. ,vol. 525, pp. 206- 211 ,(2015) , 10.1038/NATURE15251
Shiv Srivastava, Shouwen Wang, Yue Ao Tong, Zheng-Mei Hao, Esther H Chang, None, Dominant Negative Effect of a Germ-line Mutant p53: A Step Fostering Tumorigenesis Cancer Research. ,vol. 53, pp. 4452- 4455 ,(1993)
I. Martincorena, A. Roshan, M. Gerstung, P. Ellis, P. Van Loo, S. McLaren, D. C. Wedge, A. Fullam, L. B. Alexandrov, J. M. Tubio, L. Stebbings, A. Menzies, S. Widaa, M. R. Stratton, P. H. Jones, P. J. Campbell, High burden and pervasive positive selection of somatic mutations in normal human skin Science. ,vol. 348, pp. 880- 886 ,(2015) , 10.1126/SCIENCE.AAA6806
Arnold J. Levine, Moshe Oren, The first 30 years of p53: growing ever more complex Nature Reviews Cancer. ,vol. 9, pp. 749- 758 ,(2009) , 10.1038/NRC2723
Jie Xu, Joke Reumers, José R Couceiro, Frederik De Smet, Rodrigo Gallardo, Stanislav Rudyak, Ann Cornelis, Jef Rozenski, Aleksandra Zwolinska, Jean-Christophe Marine, Diether Lambrechts, Young-Ah Suh, Frederic Rousseau, Joost Schymkowitz, Gain of function of mutant p53 by coaggregation with multiple tumor suppressors Nature Chemical Biology. ,vol. 7, pp. 285- 295 ,(2011) , 10.1038/NCHEMBIO.546
Ran Brosh, Varda Rotter, When mutants gain new powers: news from the mutant p53 field Nature Reviews Cancer. ,vol. 9, pp. 701- 713 ,(2009) , 10.1038/NRC2693
Mingchao Xie, Charles Lu, Jiayin Wang, Michael D McLellan, Kimberly J Johnson, Michael C Wendl, Joshua F McMichael, Heather K Schmidt, Venkata Yellapantula, Christopher A Miller, Bradley A Ozenberger, John S Welch, Daniel C Link, Matthew J Walter, Elaine R Mardis, John F Dipersio, Feng Chen, Richard K Wilson, Timothy J Ley, Li Ding, Age-related mutations associated with clonal hematopoietic expansion and malignancies Nature Medicine. ,vol. 20, pp. 1472- 1478 ,(2014) , 10.1038/NM.3733
Bo Li, Colin N Dewey, RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome BMC Bioinformatics. ,vol. 12, pp. 323- 323 ,(2011) , 10.1186/1471-2105-12-323
Sven Heinz, Christopher Benner, Nathanael Spann, Eric Bertolino, Yin C. Lin, Peter Laslo, Jason X. Cheng, Cornelis Murre, Harinder Singh, Christopher K. Glass, Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities Molecular Cell. ,vol. 38, pp. 576- 589 ,(2010) , 10.1016/J.MOLCEL.2010.05.004