Widespread mismatch repair expression in feline small intestinal lymphomas.

摘要: Summary Small intestinal lymphoma is a common feline tumour that most often develops in older cats, but also occurs younger animals. In man, germline defects the mismatch repair (MMR) genes commonly cause hereditary non-polyposis colorectal cancer (HNPCC), or Lynch syndrome, while MMR have been implicated development of lymphoid tumours mice and people. It was hypothesized inherited predispose proportion cats to small lymphoma. expression 10 lymphomas from (group 1, mean age 4.5 years) compared with 30 2, 12.6 years). The cross-reactivity antibodies specific for human proteins MLH1, MSH2 MSH6 corresponding tissues first confirmed by western blotting. then investigated immunohistochemically lymphomas. were detected within neoplastic lymphocytes all examined. There no significant differences between two groups either intensity immunolabelling percentage cells which detected. These results confirm tissues, do not support hypothesis are