Spinal and cortical spreading depression enhance spinal cord activity.
作者： A Gorji , P.K Zahn , E.M Pogatzki , E.-J Speckmann
DOI: 10.1016/J.NBD.2003.09.014
关键词: Spinal cord 、 Cortical spreading depression 、 Spinal cord injury 、 Posterior Horn Cell 、 Premovement neuronal activity 、 Migraine 、 Neurogenic shock 、 Medicine 、 Somatosensory system 、 Neuroscience
摘要: Cortical spreading depression (CSD) has been suggested to underlie some neurological disorders such as migraine. Despite the intensity with which many investigators have studied SD in brain, only a few studies aimed identify spinal cord. Here we described main characteristic features of cord induced by different methods including various injury models and demonstrated that enhances activity following transient suppressive period. These findings suggest may play role mechanisms neurogenic shock, injury, pain. Furthermore, effect CSD on neuronal was via cortical pinprick or KCl injection somatosensory cortex. did not propagate into cervical However, intracellular recordings neurons dorsal horn C2 segment, ipsilateral hemisphere evoked, showed suppression spontaneous burst discharges, followed significant enhancement activity. This indicates link between putative cause symptoms subsequent pain
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