GL331 inhibits HIF-1α expression in a lung cancer model
作者： Hang Chang , Kou-Gi Shyu , Chun-Chung Lee , Shiow-Chwen Tsai , Bao-Wei Wang
DOI: 10.1016/S0006-291X(03)00111-6
关键词: Molecular biology 、 Adenocarcinoma 、 Western blot 、 Biology 、 Gene 、 Lung cancer 、 Messenger RNA 、 Tube formation 、 Cell biology 、 Angiogenesis 、 Northern blot
摘要: Abstract We have studied GL331’s anti-cancer mechanisms by studying their effect on the tumor-induced angiogenesis. Human lung adenocarcinoma CL1-5 cells were treated with GL331 and then maintained in serum-reduced, GL331-free medium for preparation of condition mediums. These mediums tested capability to induce vitro angiogenesis, i.e., HUVEC tube formation migration. found that generated from GL331-treated presented reduced ability inducing Western blot analyses showed both VEGF HIF-1α down-regulated cells. Northern EMSA expression without decreasing stability mRNA, decreased binding CL1-5-derived nuclear components promoter gene. Therefore, our data is a potent inhibitor The underlying might involve at least inhibition expression, probably through transcriptional repression.
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