HIF-1α and Cancer Therapy

作者: Mei Yee Koh , Taly R. Spivak-Kroizman , Garth Powis

DOI: 10.1007/978-3-540-78281-0_3

关键词:

摘要: … Based on these results, topotecan is being tested in a pilot study in patients with advanced malignancies to determine if it inhibits HIF-1α in patients with tumor over-expressing …

参考文章(148)
Hogenesch Jb, Bradfield Ca, Wartman L, Moran Sm, Gu Yz, Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. Gene Expression. ,vol. 7, pp. 205- ,(1998)
Wei Gu, Xiao-Lu Shi, Robert G. Roeder, Synergistic activation of transcription by CBP and p53 Nature. ,vol. 387, pp. 819- 823 ,(1997) , 10.1038/42972
Peter Carmeliet, Yuval Dor, Jean-Marc Herbert, Dai Fukumura, Koen Brusselmans, Mieke Dewerchin, Michal Neeman, Françoise Bono, Rinat Abramovitch, Patrick Maxwell, Cameron J. Koch, Peter Ratcliffe, Lieve Moons, Rakesh K. Jain, Désiré Collen, Eli Keshet, Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. ,vol. 394, pp. 485- 490 ,(1998) , 10.1038/28867
Won G. An, Meera Kanekal, M. Celeste Simon, Emin Maltepe, Mikhail V. Blagosklonny, Leonard M. Neckers, Stabilization of wild-type p53 by hypoxia-inducible factor 1α Nature. ,vol. 392, pp. 405- 408 ,(1998) , 10.1038/32925
Myoung Sook Kim, Ho Jeong Kwon, You Mie Lee, Jin Hyen Baek, Jae-Eun Jang, Sae-Won Lee, Eun-Joung Moon, Hae-Sun Kim, Seok-Ki Lee, Hae Young Chung, Chul Woo Kim, Kyu-Won Kim, Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. Nature Medicine. ,vol. 7, pp. 437- 443 ,(2001) , 10.1038/86507
A J Giaccia, J M Brown, The unique physiology of solid tumors: opportunities (and problems) for cancer therapy Cancer Research. ,vol. 58, pp. 1408- 1416 ,(1998)
Lynn Kirkpatrick, Garth Powis, Hypoxia inducible factor-1α as a cancer drug target Molecular Cancer Therapeutics. ,vol. 3, pp. 647- 654 ,(2004)
Gillian Paine-Murrieta, Sarah Welsh, Lynn Kirkpatrick, Ryan Williams, Garth Powis, Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1α Molecular Cancer Therapeutics. ,vol. 3, pp. 233- 244 ,(2004)
Dongming Liang, Xianguo Kong, Nianli Sang, Effects of Histone Deacetylase Inhibitors on HIF-1 Cell Cycle. ,vol. 5, pp. 2430- 2435 ,(2006) , 10.4161/CC.5.21.3409
Qing Liu, Ulrike Möller, Daniela Flügel, Thomas Kietzmann, Induction of plasminogen activator inhibitor I gene expression by intracellular calcium via hypoxia-inducible factor-1. Blood. ,vol. 104, pp. 3993- 4001 ,(2004) , 10.1182/BLOOD-2004-03-1017