Effects of Histone Deacetylase Inhibitors on HIF-1

摘要: Hypoxia inducible factors (HIF) are the master transcriptional regulators of angiogenesis and energy metabolism in mammals. Histone deacetylase inhibitors (HDAIs) among promising anti-cancer compounds currently clinical trials. In addition to inducing hyperacetylation histones, HDAIs have been found repress HIF function, which has construed as an important pharmacological mechanism underlying HDAI-mediated repression tumor growth angiogenesis. While potent function thus may be useful prevention treatment cancers, a major dilemma is that they induce non-specific targets causing side effects. A better understanding now required molecular biochemical mechanisms anti-HIF effects these compounds. Here we summarize recent advances towards mechanisms.