Bioavailability and stability of nifedipine-enteric coating agent solid dispersion.

摘要: The absorption behavior and stability of nifedipine-enteric coating agent solid dispersions were studied using hydroxypropylmethylcellulosephthalate (HP-55) methacrylic acid-methacrylic acid methyl ester copolymer (Eudragit L) as carriers. In the rat in situ study, dissolution HP-55 dispersion gastrointestinal tract was confirmed to be pH-dependent. After oral administration these beagle dog, area under blood concentration curve (AUC) values equivalent that polyvinylpyrrolidone dispersion, which showed remarkably improved bioavailability compared with nifedipine alone. These systems stable chemically physically at 40 C C/80% R. H. during 6 months, could useful sustained dosage forms good bioavailability.