Controlled release of lidocaine hydrochloride from buccal mucosa-adhesive films with solid dispersion
作者： Yukinao Kohda , Hitoshi Kobayashi , Yasuyuki Baba , Hiroshi Yuasa , Tetsuya Ozeki
DOI: 10.1016/S0378-5173(97)00241-X
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摘要: Solid dispersion films were prepared with a highly water-soluble medicine, lidocaine hydrochloride (LDC), water-insoluble ethylcellulose (EC) and hydroxypropylcellulose (HPC). The release profiles of LDC from the solid different composition, suppression mechanism in LDC-EC-HPC system studied. rate film as drug-reservoir was well controlled at EC/HPC composition ratio 5/5. speculated that there little HPC together LDC, retained swelled by permeating fluid. Then, occurred via diffusion into phase, causing marked decrease rate. for clinical use, which had 30% film, adhered almost completely to buccal mucosa. These observations will provide useful information on application film.
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