Oral bioadhesive drug delivery systems.
作者： Marcos Luciano Bruschi , Osvaldo de Freitas
DOI: 10.1081/DDC-52073
关键词:
摘要: The oral mucosal cavity is a feasible, safe, and very attractive site for drug delivery with good acceptance by users. mucosa relatively permeable robust, shows short recovery times after stress or damage, tolerant to potential allergens, has rich blood supply. Moreover, bypasses the first-pass effect avoids presystemic elimination in gastrointestinal tract. Bioadhesive systems provide intimate contact between dosage form absorbing tissue, which may result high concentration local area hence flux through tissue. efficacy of bioadhesive affected biological environment properties polymer drug. In present paper, we review systematically some relevant citations regarding environment, strategies evaluation, utilization main polymers.
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