Clinical trials of adenoviruses in brain tumors: a review of Ad-p53 and oncolytic adenoviruses.
作者： Giacomo G. Vecil , Frederick F. Lang
DOI: 10.1023/B:NEON.0000003653.45635.32
关键词: Virology 、 Clinical trial 、 Oncolytic virus 、 Brain tumor 、 Genetic enhancement 、 Virus 、 Immunotherapy 、 Glioma 、 Cancer research 、 Medicine 、 Adenoviridae
摘要: Adenoviruses have been critical in the development of molecular approaches to brain tumors. They engineered function as vectors for delivering therapeutic genes gene therapy strategies, and direct cytotoxic agents oncolytic viral therapies. This review outlines uses adenoviruses tumor by examining clinical trials adenovirus-mediated p53 reviewing application two conditionally replicative (CRAds) ONYX-015 Delta 24 The potential use CRAds that deliver trangenes, particularly p53, is also discussed.
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utsystem.edu参考文章(87)
J. Fueyo, C. Gomez-Manzano, T.-J Liu, W.K. Alfred Yung, Delivery of cell cycle genes to block astrocytoma growth. Journal of Neuro-oncology. ,vol. 51, pp. 277- 287 ,(2001) , 10.1023/A:1010661131403
Gary L. Clayman, Helmuth Goepfert, Jack A. Roth, Dorothy L. Taylor, Wei-Wei Zhang, Ta-Jen Liu, Growth Suppression of Human Head and Neck Cancer Cells by the Introduction of a Wild-Type p53 Gene via a Recombinant Adenovirus Cancer Research. ,vol. 54, pp. 3662- 3667 ,(1994)
Fadlo Khuri, James Arseneau, Ian Ganly, David Kirn, Britta Randlev, Larry Romel, Joseph Kuhn, Phillip Maples, Todd McCarty, Tony Reid, Sam Kaye, Stephen Landers, John Nemunaitis, Selective Replication and Oncolysis in p53 Mutant Tumors with ONYX-015, an E1B-55kD Gene-deleted Adenovirus, in Patients with Advanced Head and Neck Cancer: A Phase II Trial Cancer Research. ,vol. 60, pp. 6359- 6366 ,(2000)
Timothy P. Cripe, Victor Krasnykh, Yoni Y. Mahller, Edward J. Dunphy, Mark A. Currier, Jeffrey M. Bergelson, David T. Curiel, Margaret H. Collins, Neeti H. Vasi, Arvind Saini, Thomas J. Wickham, Jean D. Snyder, Alison D. Holub, James DeGregori, Fiber knob modifications overcome low, heterogeneous expression of the coxsackievirus-adenovirus receptor that limits adenovirus gene transfer and oncolysis for human rhabdomyosarcoma cells. Cancer Research. ,vol. 61, pp. 2953- 2960 ,(2001)
Anna Kanerva, Victor Krasnykh, Akseli Hemminki, Galina V. Mikheeva, Ramon Alemany, Kaori Suzuki, John T. Lam, Mack N. Barnes, David T. Curiel, Dirk M. Nettelbeck, Peter Dall, Ronald D. Alvarez, Igor Dmitriev, Gerd J. Bauerschmitz, Treatment of ovarian cancer with a tropism modified oncolytic adenovirus. Cancer Research. ,vol. 62, pp. 1266- 1270 ,(2002)
Frank McCormick, Cancer gene therapy: fringe or cutting edge? Nature Reviews Cancer. ,vol. 1, pp. 130- 141 ,(2001) , 10.1038/35101008
David F. Stojdl, Brian Lichty, Shane Knowles, Ricardo Marius, Harold Atkins, Nahum Sonenberg, John C. Bell, Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus. Nature Medicine. ,vol. 6, pp. 821- 825 ,(2000) , 10.1038/77558
Ramon Alemany, Cristina Balagué, David T. Curiel, Replicative adenoviruses for cancer therapy Nature Biotechnology. ,vol. 18, pp. 723- 727 ,(2000) , 10.1038/77283
Fadlo R. Khuri, John Nemunaitis, Ian Ganly, James Arseneau, Ian F. Tannock, Larry Romel, Martin Gore, Janet Ironside, R.H. MacDougall, Carla Heise, Britta Randlev, Ann M. Gillenwater, Patricia Bruso, Stanley B. Kaye, Waun Ki Hong, David H. Kirn, A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer Nature Medicine. ,vol. 6, pp. 879- 885 ,(2000) , 10.1038/78638
Candelaria Gomez-Manzano, W. K. Alfred Yung, Kim D. Steck, Jack A. Roth, Juan Fueyo, Victor A. Levin, Peter A. Steck, Timothy J. McDonnell, Athanassios P. Kyritsis, Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis. Cancer Research. ,vol. 56, pp. 694- 699 ,(1996)