Delivery of cell cycle genes to block astrocytoma growth.

摘要: Current therapies for glioblastoma multiforme are ineffective. Therefore, novel that target specific differences between normal and malignant cells urgently needed. Abnormalities of cell-cycle related genes a common feature cancer in general astrocytic tumors particular. The role these proteins is to help regulate cell proliferation, differentiation apoptosis. Restoring wild-type activity critical regulators the cycle generally results modification growth properties, often viability, cells. Transfer p53 induces arrest and, more importantly, Restoration Rb pathway either reversible or senescence. Expression E2F-1 transient increase proliferation followed by massive Overexpression MMAC/PTEN arrests progression G1 promotes anoikis. knowledge functions controllers can be used design small peptides drugs induce anti-cancer effect. Inactivation pathways also being engineer mutant viruses able replicate exclusively