MicroRNA-320 inhibits cell proliferation in glioma by targeting E2F1
作者： Ji‑Yong Sun , Wei‑Zhong Xiao , Fei Wang , Yong‑Qian Wang , You‑Hou Zhu
关键词: Regulation of gene expression 、 Cancer research 、 microRNA 、 Cell 、 Oncogene 、 Glioma 、 Cell cycle 、 Cell biology 、 Biology 、 Cell growth 、 E2F1
摘要: Abstract MicroRNAs (miRs) are a class of small non-coding RNAs that involved in the regulation gene expression, and cancer development progression. In present study, miR-320 expression was found to be significantly reduced glioma tissue comparison with adjacent healthy tissues. vitro analyses demonstrated overexpression inhibited cell proliferation metastasis, while antisense oligonucleotides enhanced migration U251 SHG-44 lines, compared negative control cells. Protein E2F1, cell-cycle regulator, negatively regulated by miR-320. Therefore, study provides novel insights into association between development.
sci-hub.se 参考文章(23)
J. Fueyo, C. Gomez-Manzano, T.-J Liu, W.K. Alfred Yung, Delivery of cell cycle genes to block astrocytoma growth. Journal of Neuro-oncology. ,vol. 51, pp. 277- 287 ,(2001) , 10.1023/A:1010661131403
B. Auffinger, B. Thaci, A. Ahmed, I. Ulasov, M.S. Lesniak, MicroRNA targeting as a therapeutic strategy against glioma. Current Molecular Medicine. ,vol. 13, pp. 535- 542 ,(2013) , 10.2174/1566524011313040006
Jun Sun, Huachao Shi, Niansheng Lai, Keman Liao, Shuai Zhang, Xiaojie Lu, None, Overexpression of microRNA-155 predicts poor prognosis in glioma patients. Medical Oncology. ,vol. 31, pp. 911- ,(2014) , 10.1007/S12032-014-0911-X
Yi-Ying Wu, Yuh-Ling Chen, Yun-Chia Jao, I-Shan Hsieh, Kung-Chao Chang, Tse-Ming Hong, miR-320 regulates tumor angiogenesis driven by vascular endothelial cells in oral cancer by silencing neuropilin 1. Angiogenesis. ,vol. 17, pp. 247- 260 ,(2014) , 10.1007/S10456-013-9394-1
A. Bronisz, J. Godlewski, J. A. Wallace, A.S. Merchant, M.O. Nowicki, H. Mathsyaraja, R. Srinivasan, A. J. Trimboli, C. K. Martin, F. Li, L. Yu, S. A. Fernandez, T. Pécot, T. J. Rosol, S. Cory, M. Hallett, M. Park, M. G. Piper, C. B. Marsh, L. D. Yee, R. E. Jimenez, G. Nuovo, S. E. Lawler, E. A. Chiocca, G. Leone, M. C. Ostrowski, Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320 Nature Cell Biology. ,vol. 14, pp. 159- 167 ,(2012) , 10.1038/NCB2396
Shuwei Qiu, Daquan Huang, Deling Yin, Fangcheng Li, Xiangping Li, Hsiang-fu Kung, Ying Peng, Suppression of tumorigenicity by MicroRNA-138 through inhibition of EZH2-CDK4/6-pRb-E2F1 signal loop in glioblastoma multiforme Biochimica et Biophysica Acta. ,vol. 1832, pp. 1697- 1707 ,(2013) , 10.1016/J.BBADIS.2013.05.015
McKinsey L. Goodenberger, Robert B. Jenkins, Genetics of adult glioma Cancer Genetics. ,vol. 205, pp. 613- 621 ,(2012) , 10.1016/J.CANCERGEN.2012.10.009
Kailiang Sun, Eric C. Lai, Adult-specific functions of animal microRNAs Nature Reviews Genetics. ,vol. 14, pp. 535- 548 ,(2013) , 10.1038/NRG3471
Stefan L. Ameres, Phillip D. Zamore, Diversifying microRNA sequence and function Nature Reviews Molecular Cell Biology. ,vol. 14, pp. 475- 488 ,(2013) , 10.1038/NRM3611
David Engelmann, Brigitte M. Pützer, The Dark Side of E2F1: In Transit beyond Apoptosis Cancer Research. ,vol. 72, pp. 571- 575 ,(2012) , 10.1158/0008-5472.CAN-11-2575