Mutation Rate of the CDKN2 Gene in Malignant Gliomas

摘要: The CDKN2 gene encodes p16, a protein controlling the cell cycle. is deleted in relevant number of tumor lines, but results studies primary tumors are contradictory. We have investigated by using quantitative polymerase chain reaction and single-strand conformation polymorphism analysis structure exon 2 32 malignant gliomas. In 11 amount amplified material was 21% that controls 8 it 42.3%, suggesting presence homozygous hemizygous deletions gene, respectively. However, no abnormality could be detected analysis. data confirm gliomas mechanism inactivation suggest another vicinity targeted mutations.