Deletion of p16 and p15 Genes in Brain Tumors

摘要: Abstract We have used molecular genetic methods to examine the status of cell cycle-inhibitory genes in human brain tumors. found that p16 and a neighboring gene, p15, were often homozygously deleted glioblastoma multiformes but not medulloblastomas or ependymomas. The deletions occurred both primary tumors their derived xenografts, no intragenic mutations either two found. p15 gene was expressed more widespread pattern normal tissues than p16, products had similar capacities bind cyclin D-dependent kinases 4 6. These data suggest target deletion multiforme includes genes. reason homozygous deletions, rather mutations, are so common these may be is efficient mechanism for simultaneous inactivation