CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.
作者： G Reifenberger , K Ichimura , V P Collins , E E Schmidt
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摘要: Forty-six glioblastomas, 16 anaplastic astrocytomas, and 8 astrocytomas were studied for the loss of CDKN2 (p16/MTS1) gene on 9p. The locus was homozygously deleted in 19 46 glioblastomas (41%) 1 allele lost an additional 13 cases (28%). regions limited centromerically some by MTS2 telomerically 1063.7 locus. 3 (19%) 2 further showed allele. Amplification CDK4 present 7 14 (50%) 11 (27%) with no losses at as well 32 (6%) losses. Thus one or more these two genes shown to be aberrant 85% 50% astrocytomas. None abnormalities genes.
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