A Common Region of Homozygous Deletion in Malignant Human Gliomas Lies between the IFNα/ω Gene Cluster and the D9S171 Locus

摘要: Abstract Deletions of the 9p-localized type-I interferon (IFN) genes and adjacent loci often occur during development malignant glioma. We have applied restriction fragment length polymorphism microsatellite analysis to 12 covering this region 9p 3 on 9q in 74 human glial tumor tissues define further localize smallest hemizygous or homozygous deletion common tumors. Three regions were evident among panel tumors; only one these, however, residing between D9S171 IFN α/ω gene cluster, was involved multiple cases (13 glioblastomas). Hemizygous same observed an additional 27 In total these data indicate frequent inactivation a novel suppressor centromeric gliomas.