Homozygous Deletion of the p16 Gene in Malignant Glioma

摘要: The short arm of chromosome 9 is frequently rearranged or deleted in melanoma, lung cancer, glioma, and a variety human tumors, strongly suggesting that this subchromosomal region includes tumor suppressor gene. Because the gene for p16 (also known as CDK4I MTS1) lies on 9p21 loss its function may activate G1 cyclin function, strong candidate novel To investigate frequency homozygous deletions glioma tissues cultured cell lines, DNA samples were amplified by polymerase chain reaction (PCR), determined absence PCR products As result, absent 6 lines 4 12 glioblastoma tissues. Homozygous deletion was not detected, however, any anaplastic astrocytoma 5 Deletions more common than These results indicate provide an additional growth advantage to some glioblastomas.