Loss of tumor suppressive microRNA-31 enhances TRADD/NF-κB signaling in glioblastoma

摘要: Glioblastomas (GBMs) are deadly tumors of the central nervous system. Most GBM exhibit homozygous deletions CDKN2A and CDKN2B tumor suppressors at 9p21.3, although loss CDKN2A/B alone is insufficient to drive gliomagenesis. MIR31HG, which encodes microRNA-31 (miR-31), a novel non-coding suppressor positioned adjacent 9p21.3. We have determined that miR-31 expression compromised in >72% all GBM, for patients, this predicts significantly shortened survival times independent status. show inhibits NF-κB signaling by targeting TRADD, its upstream activator. Moreover, upon reintroduction, reduces burden lengthens animal models. As such, our work identifies as tumor-driving event GBM.