Molecular neuropathology of astrocytic brain tumors.

摘要: Both surgical and molecular neuropathologists have recently achievedremarkable progress in the histogenetic classification molecularcharacterization of human gliomas. Major histopathological achievements inthe revised WHO include introduction ofimmunohistochemical reagents for glial fibrillary acidic protein andfor proliferation-associated antigens, definition glioblastomamultiforme as an astrocytic neoplasm recognitionof pleomorphic xantho- astrocytomas a novelclinico-pathological entity.In neuropathology, alterations oncogenes tumorsuppressor genes their potential functions beenidentified, microsatellite analyses revealed novel loci forputative tumor suppressor distinct pathwaysfor different entities are beginning to emerge.Mutations cell cycle regulatory presentin most glioblastomas may account theirstriking growth potential. Autocrine paracrine factorsand respective tyrosine kinase receptors appearto contribute both endothelial cellproliferation.In our contribution, we would like focuson Findings with diagnostic relevanceinclude changes associated malignant progression lowgrade astrocytomas, patterns genetic which allowto further differentiate such theglioblastoma multiforme into genetically subsets mechanismsof angiogenesis gliomas.One major tasks ahead is toestablish correlations relationships between histopathological, andclinical data. This will require long-term collaborationbetween neuropathologists, neurosurgeons clinical neuro-oncologists.