Molecular genetic alterations in glioblastomas with oligodendroglial component.

摘要: Glioblastoma multiforme is the most malignant astrocytic glioma and usually resistant to chemotherapy. A small fraction of glioblastomas may contain areas with histological features oligodendroglial differentiation. To determine molecular genetic alterations in such "glioblastomas component", we investigated 13 these tumors for and/or expression TP53, CDKN2A, PTEN, EGFR genes. In addition, performed microsatellite analyses loss heterozygosity (LOH) on chromosome arms 1p, 19q 10q. None showed evidence LOH 1p was detected 3 tumors, 1 which additionally 19q. The neither TP53 mutations nor nuclear p53 accumulation. contrast, 9 10 without demonstrated losses were identified cases. Further aberrations epidermal growth factor receptor (EGFR) overexpression (3 tumors), homozygous CDKN2A deletion (2 11 PTEN mutation (1 tumors). Taken together, our results indicate that component" carry heterogeneous alterations. 10q, mutation, appear be less common as compared ordinary glioblastomas. Furthermore, a subset demonstrates i.e., an alteration has recently been linked chemosensitivity good prognosis anaplastic oligodendrogliomas.