Chemotherapy for anaplastic oligodendroglioma. National Cancer Institute of Canada Clinical Trials Group.
作者： G Cairncross , D Macdonald , S Ludwin , D Lee , T Cascino
DOI: 10.1200/JCO.1994.12.10.2013
关键词: Phases of clinical research 、 Oligodendroglial Tumor 、 Oligoastrocytoma 、 Medicine 、 Procarbazine 、 Internal medicine 、 Lomustine 、 Oligodendroglioma 、 Chemotherapy 、 Vincristine 、 Surgery
摘要: PURPOSETo examine the rate and duration of response anaplastic oligodendrogliomas to a dose-escalated combination chemotherapy regimen consisting procarbazine, lomustine (CCNU), vincristine (PCV) evaluate side effects this treatment.METHODSIn single-arm multicentered phase II study, patients with measurable, newly diagnosed or recurrent, contrast-enhancing were treated up six cycles PCV. Central pathology radiology review mandatory, rigorous criteria based on imaging used.RESULTSThirty-three entered trial; nine excluded subsequently, seven due ineligible pathology. Eighteen 24 eligible (75%) responded, completely (38%), four had stable disease (SD), two progressed during first cycle Responses observed in 10 (90%) preexisting low-grade oligodendroglioma 15 (67%) necrotic tumors, called glioblastoma multiforme by so...
elsevier.com
sci-hub.se 参考文章(31)
Edwards Ms, Seager Ml, Townsend Jj, Schimberg Tp, Wright Dc, Wilson Cb, Levin Va, Modified procarbazine, CCNU, and vincristine (PCV 3) combination chemotherapy in the treatment of malignant brain tumors. Cancer treatment reports. ,vol. 64, pp. 237- 244 ,(1980)
Brambilla C, Valagussa P, Solero Cl, Morello G, Vaghi A, Bonadonna G, Monfardini S, Controlled study with BCNU vs. CCNU as adjuvant chemotherapy following surgery plus radiotherapy for glioblastoma multiforme. Cancer clinical trials. ,vol. 2, pp. 43- 48 ,(1979)
Lucien Jules Rubinstein, Tumors of the central nervous system Armed Forces Institute of Pathology; sold by American Registry of Pathology. ,(1972)
J. Ransohoff, C. B. Wilson, M. D. Walker, S. B. Green, D. P. Byar, J. T. Robertson, J. Mealey, W. R. Shapiro, R. G. Selker, T. A. Strike, W. H. Brooks, K. R. Smith, P. Paoletti, U. Batzdorf, G. L. Odom, D. A. Pistenmaa, W. E. Hunt, E. Alexander, Comparisons of carmustine, procarbazine, and high-dose methylprednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma. Cancer treatment reports. ,vol. 67, pp. 121- 132 ,(1983)
Michael T. Smith, Carol L. Ludwig, Alfred D. Godfrey, V. W. Armbrustmacher, Grading of oligodendrogliomas Cancer. ,vol. 52, pp. 2107- 2114 ,(1983) , 10.1002/1097-0142(19831201)52:11<2107::AID-CNCR2820521123>3.0.CO;2-X
Tomasz Trojanowski, Jerzy P\ceszyński, Krzysztof Turowski, Stanisław Kamiński, Igor Gościński, Marian Reinfus, Tadeusz Krzyszkowski, Marek Pyrich, Adam Bielawski, Czesława Leszczyk, Barbara Bendarzewska, Andrzej Staszczak, Halina Koźniewska, Postoperative radiotherapy and radiotherapy combined with CCNU chemotherapy for treatment of brain gliomas. Journal of Neuro-oncology. ,vol. 6, pp. 285- 291 ,(1988) , 10.1007/BF00163714
Jon Glass, Fred H. Hochberg, Michael L. Gruber, David N. Louis, David Smith, Barbara Rattner, The treatment of oligodendrogliomas and mixed oligodendroglioma-astrocytomas with PCV chemotherapy Journal of Neurosurgery. ,vol. 76, pp. 741- 745 ,(1992) , 10.3171/JNS.1992.76.5.0741
W. J. Curran, C. B. Scott, J. Horton, J. S. Nelson, A. S. Weinstein, A. J. Fischbach, C. H. Chang, M. Rotman, S. O. Asbell, R. E. Krisch, D. F. Nelson, Recursive Partitioning Analysis of Prognostic Factors in Three Radiation Therapy Oncology Group Malignant Glioma Trials Journal of the National Cancer Institute. ,vol. 85, pp. 704- 710 ,(1993) , 10.1093/JNCI/85.9.704
Yukitaka Ushio, Toru Hayakawa, Hiroshi Hasegawa, Kazuo Yamada, Norio Arita, Chemotherapy of malignant gliomas Neurosurgical Review. ,vol. 7, pp. 3- 12 ,(1984) , 10.1007/BF01743285
J. G. Cairncross, D. R. Macdonald, J. H. Warwick Pexman, F. J. Ives, Steroid-induced CT changes in patients with recurrent malignant glioma Neurology. ,vol. 38, pp. 724- 724 ,(1988) , 10.1212/WNL.38.5.724