Oligodendroglial Tumors: Intra-arterial Chemotherapy

摘要: Brain tumors with an oligodendroglial component represent up to 20% of all primary brain tumors. Many these are sensitive procarbazine, lomustine and vincristine (PCV), or temozolomide (TMZ) chemotherapy. In patients that resistant PCV TMZ chemotherapy, few treatment options available improved therapy is needed. One strategy, administration chemotherapy via the intra-arterial (IA) route, can result in a higher concentration drug delivery tumor cells, lower systemic exposure, resulting increased tumor-specific cytotoxicity, avoidance toxicities. Osmotic blood-brain barrier disruption (BBBD), achieved by IA infusion hyperosmotic agent such as mannitol, further intensify surrounding brain, particularly smaller, less permeable when using higher-molecular weight agents. General experience combined BBBD many types extensive. case aggressive tumors, hopeful results have been reported combination (IA melphalan, carboplatin IV etoposide phosphate) conjunction BBBD, acceptably low toxicity encouraging response data patients. Delivery may be good option those Further work required uncover true potential setting