Chemotherapy delivery issues in central nervous system malignancy: a reality check.
作者： Leslie L. Muldoon , Carole Soussain , Kristoph Jahnke , Conrad Johanson , Tali Siegal
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摘要: Purpose This review assesses the current state of knowledge regarding preclinical and clinical pharmacology for brain tumor chemotherapy evaluates relevant studies before October 2006. Results Chemotherapeutic regimens in therapy have often emerged from empirical with retrospective pharmacologic explanations, rather than prospective trials rational chemotherapeutic approaches. Brain tumors are largely composed CNS metastases systemic cancers. Primary tumors, such as glioblastoma multiforme or primary lymphomas, less common. Few these well-defined optimal treatment. protected by blood-brain barrier (BBB) intrinsic properties tumors. Pharmacologic delivery conventional chemotherapeutics novel therapeutics showing actual concentrations biologic effect lacking. Conclusion In this article, we drug across BBB, well blood-tumor ‐cerebrospinal fluid (CSF) barriers, mechanisms to increase CSF Because difficulty treating innovative treatments alternative techniques involving brain/cord capillaries, choroid plexus, needed. J Clin Oncol 25:2295-2305. © 2007 American Society Clinical Oncology
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