Differential permeability and quantitative MR imaging of a human lung carcinoma brain xenograft in the nude rat.

摘要: This study characterized agent differential permeability, three-dimensional tumor volume, and survival in an LX-1 human small cell lung carcinoma intracerebral xenograft model the nude rat. The percent accessible tissue space (distribution volume) permeability x capillary surface product for aminoisobutyric acid (M(r) 103), methotrexate 454), dextran 10 10,000), 70 70,000) were measured between 8 16 days after inoculation of tumor. Magnetic resonance imaging histology used to quantitate volume (mm3). Accessible (ml/g) intracranial tumor, surrounding brain, subcutaneous decreased with increasing molecular weight agent, regardless number inoculation. increased all agents except 70. There was little change or other tissues time. Tumor calculations from studies correlated volumetric measurements histological sections (r2 = 98.5%) illustrated natural progression (9 225 mm3). These results provide a basis therapeutic design based on specific ability quantitatively measure brain accessing response.