Regional blood‐to‐tissue transport in avian sarcoma virus (ASV)‐induced brain tumors

摘要: Regional blood-to-tissue transport of 14 C-alpha-aminoisobutyric acid (AIB) was measured in avian sarcoma virus (ASV)-induced rat brain tumors and expressed as a unidirectional transfer rate constant (K). The magnitude K variable did not correlate with histologic classification or specific features the tumors, possible exception sarcomas. Averaged mean highest for anaplastic astrocytomas lowest gemistocytic (GA); however, range measurement within individual tumor classifications (except GA) broad. consistently related to size location; choroid plexus subependymal were exceptions had higher values. averaged tumor-free contralateral hemisphere (CBA) comparable that control animals. adjacent greater than CBA generally one-third one-half value periphery, indicating these affect permeability characteristics capillaries. Estimates fractional extraction (E) AIB by ranged between 0.009 0.2; E9s this indicate capillaries are freely permeable solute.