Pharmacology and neurotoxicity of cis-diamminedichloroplatinum, bleomycin, 5-fluorouracil, and cyclophosphamide administration following osmotic blood-brain barrier modification.

摘要: cis-Platinum, bleomycin, 5-fluorouracil, and cyclophosphamide were administered to rodent canine models of osmotic blood-brain barrier modification evaluate the relationship between tissue drug concentration in brain physiological neuropathological effects drug. The toxicity studies carried out canine, pharmacological rodent. Even without procedure, intracarotid cis-platinum, contrast other drugs, produced with resultant severe neurotoxicity. Osmotic was used increase delivery bleomycin 5-fluorouracil ipsilateral region, but increased associated evident Cyclophosphamide administration association opening did not cause significant neural toxicity. These indicate that some chemotherapeutic agents given can result corollary known limited neurotoxicity when these are a conventional manner appears be due presence barrier.