Reversible osmotic blood-brain barrier disruption in humans: implications for the chemotherapy of malignant brain tumors.

摘要: The blood-brain barrier seems to be an important factor in drug access malignant brain tumors. Successful experimental reversible disruption of the animals provided basis for a clinical evaluation osmotic five patients with primary and metastatic Good excellent was achieved four single nontransient complication, superficial wound infection at burr hole site first patient. Reversible, transient 15 times without additional toxicity. Computed tomography radionuclide imaging were shown useful noninvasive monitors adequacy extent disruption. These studies also provide further evidence that is least partially intact human tumors because one patient metastsis seen only after