Osmotic opening of the blood-brain barrier: principles, mechanism, and therapeutic applications.

摘要: 1. Osmotic opening of the blood-brain barrier by intracarotid infusion a hypertonic arabinose or mannitol solution is mediated vasodilatation and shrinkage cerebrovascular endothelial cells, with widening interendothelial tight junctions to an estimated radius 200 A. The effect may be facilitated calcium-mediated contraction cytoskeleton. 2. marked increase in apparent permeability intravascular substances (10-fold for small molecules) following osmotic procedure due both increased diffusion bulk fluid flow across junctions. largely reversed within 10 min. 3. In experimental animals, method has been used grant wide access brain water-soluble drugs, peptides, antibodies, boron compounds neutron capture therapy, viral vectors gene therapy. also together anticancer drugs treat patients metastatic primary tumors, some success minimal morbidity.