摘要: The blood-brain barrier at cerebral blood vessels is due to a continuous lining of endothelial cells, which are connected by tight junctions that restrict intercellular diffusion. endothelium excludes most water-soluble solutes and proteins but supports facilitated stereospecific transport monosaccharides large neutral basic amino acids. in different species can be made permeable infusing hypertonic solution urea or arabinose into the internal carotid artery. Endothelial cells presumably shrink between them widen normally restricted solutes. Thus, intravascular protein tracers such as Evans' blue-albumin, 125I-labelled albumin, horseradish peroxidase (ED 1.11.1.7) alpha-mannosidase (EC 3.2.1.24) allowed brain, uptake [3H] norepinephrine (noradrenaline) increased more than twofold above normal rate accumulation brain. Osmotic opening amines has been used demonstrate their effect on flow from within brain parenchyma. reversible, may graded with respect molecular size not followed evidence damage oedema (when measured two days after infusion). Transient changes probably accompany osmotic opening, however, glucose metabolism infusion.
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