Rat brain tumor models in experimental neuro-oncology:The 9L, C6, T9, F98, RG2 (D74), RT-2 and CNS-1 Gliomas

摘要: Rat brain tumor models have been widely used in experimental neuro-oncology for almost three decades. The present review, which will be selective rather than comprehensive, focus entirely on seven rat and their utility evaluating the efficacy of various therapeutic modalities. Although no currently available animal model exactly simulates human high grade tumors, that are provided a wealth information vitro vivo biochemical biological properties tumors responses to Ideally, valid should derived from glial cells, grow with predictable reproducible growth patterns simulate gliomas, weakly or non-immunogenic, response therapy, lack thereof, resemble tumors. following discussed. 9L gliosarcoma, was chemically induced an inbred Fischer rat, has one most all much useful relating biology therapy. T9 glioma, although generally unrecognized, probably still is same as 9L. Both these can immunogenic under appropriate circumstances, this must taken into consideration when using either them studies efficacy, especially if survival endpoint. C6 outbred Wistar extensively variety studies, but not syngeneic any strain. Its potential evoke alloimmune serious limitation, it being studies. F98 RG2 (D74) gliomas were both appear non-immunogenic. These refractory modalities invasive pattern uniform lethality innoculum few 10 cells make particularly attractive test new Avian Sarcoma Virus continuous cell line them, designated RT-2, de novo induction important requirement. however, may limit usefulness Finally, recently described, CNS-1, appears number neuro-oncology. It essential recognize, limitations each depending upon nature study conducted, selected.