Transformation of Normal Astrocytes Into a Tumor Phenotype
作者： Sean E. Aeder , Isa M. Hussaini
DOI: 10.1007/978-1-59745-021-8_30
关键词: Growth factor 、 Transformation (genetics) 、 Cell biology 、 Protein kinase C 、 Cell cycle 、 Astrocyte 、 Astrocytoma 、 Tumor phenotype 、 Biology 、 Cell culture
摘要: Genetic alterations leading to changes in cell cycle regulation and growth factor signaling transform astrocytes into a tumor phenotype. This chapter describes four grades of astrocytic tumors, discusses how genetic lead astrocyte transformation, stresses networks contribute this transformation. Finally we discuss lines animal models pertinent the study tumors.
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