A Novel p16INK4A Transcript

摘要: p16INK4A and p15INK4B were initially identified as potent inhibitors of activated cyclin/cyclin-dependent kinase complexes. These genes colocalized to chromosome 9p21, p16 was subsequently found be mutated in familial melanoma deleted a wide variety sporadic cancers. We recently that de novo methylation 5′ CpG island led transcriptional block full-length many neoplasms. However, the presence truncated transcript methylated cell lines us investigate an alternative promoter or initiation site. have now abundant both unmethylated generated from novel sequence (exon 1β) potentially involved complex regulation these critical cycle genes.