Molecular Genetics of Tumors of the Central Nervous System
作者： C. David James
DOI: 10.1385/1-59259-843-9:019
关键词:
摘要: 1985 marked the first reporting of a specific gene alteration in human central nervous system (CNS) tumor: epidermal growth factor receptor (EGFR) amplification glioblastoma (43). Since that time, relatively short period by most standards, neuro-oncology research has revealed many genetic abnormalities indicate consistent genotype-phenotype associations for various cancers are collectively referred to as CNS tumors. This chapter reviews established tumor genotype associations, and discusses resulting molecular biologic consequences well clinical implications these alterations.
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