The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo
作者： J. T. Huse , C. Brennan , D. Hambardzumyan , B. Wee , J. Pena
DOI: 10.1101/GAD.1777409
关键词: Protein kinase B 、 Loss of heterozygosity 、 Tensin 、 PTEN 、 Biology 、 Glioma 、 Regulation of gene expression 、 PI3K/AKT/mTOR pathway 、 Cancer research 、 microRNA
摘要: … monoallelic PTEN loss. Finally, we demonstrate that miR-26a-mediated PTEN repression in … heterozygosity and the PTEN locus. Our results document a new epigenetic mechanism for …
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