Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice

摘要: Basic fibroblast growth factor (bFGF) is overexpressed in most high-grade human gliomas, implying that it involved the pathogenesis of these tumors. To assess biological effect inappropriate production bFGF normal astrocytes, we developed a system for glia-specific gene transfer transgenic mice. A transgene encoding receptor subgroup avian leukosis virus and controlled by astrocyte-specific glial fibrillary acidic protein promoter permits efficient genes carried vectors. With this system, have demonstrated induces proliferation migration cells vivo, without induction